Contribution of the SPATAX network to the identification of 18 new causative genes

Three members of the SPATAX network (Cairo, Rabat and Paris), including a research team (Inserm/CNRS/UPMC/EPHE) of the ICM institute took part to an international study leaded by Joseph Gleeson (San Diego) identifying 18 new genes implicated in hereditary spastic paraplegias (HSP). This work, published on January the 31th on the prestigious website of the journal Science, arises from a worldwide collaboration and strongly contributes to the understanding of the genetic origin of HSP, a prerequisite to future therapies, and to future identification of new causative genes.

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Spatax members are in bold

Novarino G, Fenstermaker AG, Zaki MS, Hofree M, Silhavy JL, Heiberg AD, Abdellatef M, Rosti B, Scott E, Mansour L, Masri A, Kayserili H, Al-Aama JY, Abdel-Salam GMH, Karminejad A, Kara M, Kara B, Bozorgmehri B, Ben-Omran T, Mojahedi F, El Din Mahmoud IG, Bouslam N, Bouhouche A, Benomar A, Hanein S, Raymond L, Forlani S, Mascaro M, Selim L, Shehata N, Al-Allawi N, Bindu PS, Azam M, Gunel M, Caglayan A, Bilguvar K, Tolun A, Issa MY, Schroth J, Spencer EG, Rosti RO, Akizu N, Vaux KA, Johansen A, Koh AA, Megahed H, Durr A, Brice A, Stevanin G, Gabriel S, Ideker T, Gleeson J. Whole Exome Sequencing Links Corticospinal Motor Neuron Disease to Common Neurodegenerative Disorders. Science 2014, 343:506-511 (online January 31)