6th International Meeting on Spastic Paraparesis and Ataxia, September 20-21 2019 in Nice (South of France)

(Satellite meeting of the international congress of Parkinson’s disease and Movement Disorders – MDS 2019, 22-26/9/2019)



LOCATION: Acropolis – Palais des congrès et des expositions, Nice, France



ORGANIZATION: Organized by the SPATAX network, the Ataxia Study Group and the PREPARE_Ataxia consortium


SCIENTIFIC COMMITTEE: Sylvia Boesch (Austria), Alexandra Durr (France), Filippo Santorelli (Italy), Giovanni Stevanin (France), Matthis Synofzik (Germany), Chantal Tallaksen (Norway), Bart Van de Warrenburg (Netherlands)

LOCAL COMMITTEE: Alexandra Durr (ICM, APHP, Sorbonne University, France), Giovanni Stevanin (ICM, INSERM, EPHE, Paris Sciences Lettres Research University, France).

GOAL: Members of the SPATAX Network, PREPARE_Ataxia consortium and Ataxia Study Group (ASG) and researchers from all over the world will meet in Nice from 20 to 21 September 2019 in a satellite meeting of the International Parkinson and Movement Disorder Society congress. The program includes plenary talks from leaders in the field of spinocerebellar diseases (dominant and recessive forms of cerebellar ataxias and spastic paraplegias), round tables and short talks or poster presentations from junior researchers.

ABSTRACTS: Junior scientists are encouraged to submit abstracts before June 30 to spatax@icm-institute.org (with unpublished data). They will be selected by the board for poster (70 slots available) or oral presentation (9 slots available). All selected abstracts will be published in Frontiers in Neurology.

Author 1 [first name and family name] (1), Author 2 (2,3). (1) Institute X, Paris, France; (2) Institute XX, Rome, Italy; (3) Hospital Y, Madrid, Spain.
Body of the text (250 words Max, 1 table or figure Max).


INFORMATION & ABSTRACTS: spatax@icm-institute.org


Registration fees (credit card only) include access to the conferences and poster zone, coffee breaks and lunches indicated in the planning (housing and travel at your own charge except invited speakers; space is limited, then register early): (i) Students (valid student card ID needed), patient representatives (1 per association) and invited speakers: free; (ii) SPATAX/ASG/PREPARE members: 210 euros; (iii) Non members or registration after July 15: 360 euros.

SPONSORS OF THE EVENT: SPATAX, E-Rare PREPARE_Ataxia, DYNACURE, Tom Wahlig Foundation, Spastic Paraplegia Foundation US, ASL-France, AIViPS-Italy, CSC, NASPA, The Maddi Foundation, ADCA vereniging Nederland, AFAF, ROCHE, EURO-HSP, National Ataxia Foundation US



PROGRAM (version March 2019)

DAY 1: September, Friday 20th 2019

13:00 Welcome coffee, Registration (Opening of Poster zone)

13:45 Welcoming session by the local scientific committee

13:50 Presentation of the patient associations sponsoring the event

14:00 Plenary conferences (20’+10’ questions) Chair: Filippo Santorelli

  • Hélène Puccio (France) Recent insight into the cerebellar dysfunction in ARCA2 linked to COQ8A/ADCK3 mutations
  • Agnès Rötig (France) Impaired regulation of cytosolic iron homeostasis in Friedreich ataxia

15:00   Selected abstracts 1 and 2

15:30 – 16:15 Coffee break and Poster session 1

16:15 Plenary conferences (20’+10’ questions) Chair: Frédéric Darios

  • Fanny Mochel (France) Metabolic forms of neurodegenerative disorders
  • Frederic Vaz (Netherlands) Characterization of lipid metabolism in hereditary spastic paraplegias using lipidomics

17:15   Selected abstracts 3 and 4

17:45 Networks news (10’ each with 10’ final discussion) Chair: Alexis Brice

  • Thomas Klockgether (Germany) SCA global
  • Matthis Synofzik (Germany) ARCA global
  • Rebecca Schüle (Germany) TreatHSP.net and the Alliance for Treatment in HSP and PLS
  • Alexandra Durr (France) Spatax database to setup a TransNational HSP network
  • General discussion (10 mn)

18:40 End of the meeting (Poster zone closed)

20:00 – 00:00 Social Spatax-Prepare event in Nice

DAY 2: September, Saturday 21st 2019

8:30 Welcome coffee (Opening of Poster zone)

9:00 Plenary conferences (20’+10’ questions) Chair: Sylvia Boesch

  • Rebecca Schüle (Germany) IP3 Receptor Degradation – A Mutational Hotspot for Hereditary Ataxia and Motor Neuron Disease
  • André Van Kuilenburg (Netherlands) Glutaminase deficiency, a Novel Repeat Expansion Disorder identified through Deep Phenomics and Genomics

10:00 Selected abstract 5

10:15 – 11:00 Group photo, Coffee break and Poster session 2

11:00 Plenary conferences (20’+10’ questions) Chair: Antoni Matilla Dueñas

  • Henry Houlden (Great Britain) A novel repeat involved in CANVAS
  • Isabel Silveira (Portugal) A non-coding repeat insertion causes spinocerebellar ataxia type 37

12:00   Selected abstract 6

12:15 – 13:45 Lunch offered to all participants and Poster session 3

13:45 Plenary conferences (20’+10’ questions) Chair: Chantal Tallaksen

  • Juan Bonifacio (United-States) Novel Insights into AP-4-Deficiency Syndrome
  • Gulin Oz (United-States) MRI and MRS readouts in Spinocerebellar Ataxias

14:45   Selected abstracts 7 and 8

15:15 – 16:15 Coffee break and Poster session 4 (Poster votes and poster removal at 16:15)

(15:15 – 15:45: Debriefing with patient associations representatives and the scientific committee)

16:15 Plenary conferences (20’+10’ questions) Chair: Matthis Synofzik

  • Bernard Brais (Quebec) New insights on ARSACS lead to a search for candidate compounds
  • Frédéric Darios (France) From physiopathology to preclinical trials in SPG11

17:15   Selected abstract 9

17:30 Round-Table Discussion on Therapy (10 mn presentations, 35 mn discussion with the public) Chair: Bart Van de Warrenburg

  • Mimoun Azzouz (UK) Gene therapeutics for spastic paraplegia types 15 and 47
  • Lucy Vincent (France) Dance for ataxias and spastic paraplegias
  • Matthis Synofzik (Germany) Exergames and physiotherapy
  • Sander Geurts (Netherlands) Botulinum toxin

18:45 – 19:00 Closing ceremony – Prizes for the best posters

Sponsored by: SPATAX, E-Rare PREPARE_Ataxia, DYNACURE, Tom Wahlig Foundation, Spastic Paraplegia Foundation US, ASL-France, AIViPS-Italy, CSC, NASPA, The Maddi Foundation, ADCA vereniging Nederland, AFAF, ROCHE, EURO-HSP, National Ataxia Foundation US